Compounds > 4-[(1-methyl-5-tetrazolyl)thio]-5-[3-(trifluoromethyl)phenyl]thieno[2,3-d]pyrimidine
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4-[(1-methyl-5-tetrazolyl)thio]-5-[3-(trifluoromethyl)phenyl]thieno[2,3-d]pyrimidine

Description

4-[(1-methyl-5-tetrazolyl)thio]-5-[3-(trifluoromethyl)phenyl]thieno[2,3-d]pyrimidine : no description available [CHeBI]

Cross-References

ID SourceID
PubMed CID44142133
CHEMBL ID1496788
CHEBI ID92639

Synonyms (9)

Synonym
NCGC00182359-01
smr001317751
MLS002264450
HMS2194P23
HMS3356D09
CHEMBL1496788
CHEBI:92639
4-[(1-methyl-5-tetrazolyl)thio]-5-[3-(trifluoromethyl)phenyl]thieno[2,3-d]pyrimidine
Q27164349

Drug Classes (2)

ClassDescription
aryl sulfideAny organic sulfide in which the sulfur is attached to at least one aromatic group.
thienopyrimidineA class of aromatic heterobicyclic compounds each of which contains a pyrimidine ring ortho fused to a 5-membered thiophene ring.

Protein Targets (17)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)
Nrf2Homo sapiens (human)Potency0.5623AID624171
ATAD5 protein, partialHomo sapiens (human)Potency20.5878AID504467
Smad3Homo sapiens (human)Potency10.0000AID588855
vitamin D3 receptor isoform VDRAHomo sapiens (human)Potency56.2341AID504847
nuclear factor erythroid 2-related factor 2 isoform 2Homo sapiens (human)Potency29.0929AID504444
parathyroid hormone/parathyroid hormone-related peptide receptor precursorHomo sapiens (human)Potency56.2341AID743266
huntingtin isoform 2Homo sapiens (human)Potency10.4710AID2669; AID2672; AID2673
DNA polymerase iota isoform a (long)Homo sapiens (human)Potency12.5893AID588590
urokinase-type plasminogen activator precursorMus musculus (house mouse)Potency8.9125AID540303
plasminogen precursorMus musculus (house mouse)Potency8.9125AID540303
urokinase plasminogen activator surface receptor precursorMus musculus (house mouse)Potency8.9125AID540303
gemininHomo sapiens (human)Potency3.2643AID624296; AID624297
DNA dC->dU-editing enzyme APOBEC-3G isoform 1Homo sapiens (human)Potency14.1254AID602310

Activation Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)
Phosphatidylinositol 5-phosphate 4-kinase type-2 gammaHomo sapiens (human)Kd6.3000AID1260401

Other Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)
PAX8Homo sapiens (human)AC503.4100AID687027
MSHDrosophila melanogaster (fruit fly)AC505.9700AID743444
HuntingtinHomo sapiens (human)AC5019.5125AID1260397; AID1260398; AID1260399; AID1260400

Bioassays (7)

Assay IDTitleYearJournalArticle
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13ISSN: 1934-9300Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
ISSN: 1552-4922		Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
ISSN: 1557-8127		High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13ISSN: 1934-9300Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
ISSN: 1552-4922		Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
ISSN: 1557-8127		High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13ISSN: 1934-9300Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
ISSN: 1552-4922		Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
ISSN: 1557-8127		High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID504810Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
ISSN: 1945-7170		A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID1745845Primary qHTS for Inhibitors of ATXN expression2022The Journal of biological chemistry, 08, Volume: 298, Issue:8
ISSN: 1083-351X
AID651635Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression2022The Journal of biological chemistry, 08, Volume: 298, Issue:8
ISSN: 1083-351X
AID504812Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
ISSN: 1945-7170		A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (20.00)29.6817
2010's3 (60.00)24.3611
2020's1 (20.00)2.80

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
SubstanceStudiesClassesRolesFirst YearLast YearAverage AgeRelationship StrengthTrialspre-19901990's2000's2010'spost-2020
albendazole
0
aryl sulfide;
benzimidazoles;
benzimidazolylcarbamate fungicide;
carbamate ester		anthelminthic drug;
microtubule-destabilising agent;
tubulin modulator		00low000000
azathioprine
0
aryl sulfide;
C-nitro compound;
imidazoles;
thiopurine		antimetabolite;
antineoplastic agent;
carcinogenic agent;
DNA synthesis inhibitor;
hepatotoxic agent;
immunosuppressive agent;
prodrug		00low000000
bithionol
0
aryl sulfide;
bridged diphenyl antifungal drug;
bridged diphenyl fungicide;
dichlorobenzene;
organochlorine pesticide;
polyphenol		antifungal agrochemical;
antiplatyhelmintic drug		00low000000
fenbendazole
0
aryl sulfide;
benzimidazoles;
carbamate ester		antinematodal drug00low000000
methiothepin
0
aryl sulfide;
dibenzothiepine;
N-alkylpiperazine;
tertiary amino compound		antipsychotic agent;
dopaminergic antagonist;
geroprotector;
serotonergic antagonist		00low000000
1-(ethoxymethyl)-5-isopropyl-6-(phenylsulfanyl)uracil
0
aryl sulfide;
pyrimidone		00low000000
2,3-bis[amino-[(2-aminophenyl)thio]methylidene]butanedinitrile
0
aryl sulfide00low000000
pirinixic acid
0
aryl sulfide;
organochlorine compound;
pyrimidines		00low000000
fentichlor
0
aryl sulfide;
bridged diphenyl antifungal drug;
monochlorobenzenes;
polyphenol		antiinfective agent;
drug allergen		00low000000
methylphenylsulfide
0
aryl sulfide;
benzenes		00low000000
diphenyl sulfide
0
aryl sulfide00low000000
methiocarb
0
aryl sulfide;
carbamate ester;
methyl sulfide		acaricide;
agrochemical;
avicide;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
environmental contaminant;
insecticide;
molluscicide;
xenobiotic		00low000000
pipazethate
0
aryl sulfide00low000000
butoconazole nitrate
0
aryl sulfide;
conazole antifungal drug;
imidazole antifungal drug;
imidazoles;
organic nitrate salt		00low000000
butoconazole
0
aryl sulfide;
conazole antifungal drug;
dichlorobenzene;
imidazole antifungal drug;
imidazoles;
monochlorobenzenes		00low000000
fenticonazole
0
aryl sulfide;
dichlorobenzene;
ether;
imidazoles		00low000000
nelfinavir
0
aryl sulfide;
benzamides;
organic heterobicyclic compound;
phenols;
secondary alcohol;
tertiary amino compound		antineoplastic agent;
HIV protease inhibitor		00low000000
1-((2-hydroxyethoxy)methyl)-6-(phenylthio)thymine
0
aryl sulfide;
primary alcohol;
pyrimidone		antiviral drug;
HIV-1 reverse transcriptase inhibitor		00low000000
anpirtoline
0
aryl sulfide00low000000
azintamid
0
aryl sulfide00low000000
tiazuril
0
aryl sulfide00low000000
g 25671
0
aryl sulfide00low000000
irgarol 1051
0
aryl sulfide;
cyclopropanes;
diamino-1,3,5-triazine		antifouling biocide;
environmental contaminant;
xenobiotic		00low000000
8-((4-chlorophenyl)thio)cyclic-3',5'-amp
0
3',5'-cyclic purine nucleotide;
adenyl ribonucleotide;
aryl sulfide;
organochlorine compound		protein kinase agonist00low000000
zofenopril
0
aryl sulfide;
L-proline derivative;
N-acyl-L-amino acid;
thioester		anticonvulsant;
apoptosis inhibitor;
cardioprotective agent;
EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor;
prodrug;
vasodilator agent		00low000000
bnps-skatole
0
aryl sulfide;
bromoindole;
C-nitro compound		reagent00low000000
5-(Ethylthio)-1,3,4-thiadiazol-2-amine
0
aryl sulfide00low000000
2-(s-glutathionyl)hydroquinone
0
aryl sulfide;
glutathione conjugate;
hydroquinones		human xenobiotic metabolite;
nephrotoxic agent		00low000000
2-s-cysteinyldopa
0
amino dicarboxylic acid;
aryl sulfide;
catechols;
diamine;
L-tyrosine derivative;
S-conjugate;
S-organyl-L-cysteine		human urinary metabolite00low000000
2-methyl-3-(phenylthio)pyrazine
0
aryl sulfide00low000000
3-(prop-2-enylthio)-5-thiophen-2-yl-1H-1,2,4-triazole
0
aryl sulfide00low000000
5-[(4-chlorophenyl)methylthio]-1,3,4-thiadiazol-2-amine
0
aryl sulfide00low000000
pd 173955
0
aryl sulfide;
dichlorobenzene;
methyl sulfide;
pyridopyrimidine		tyrosine kinase inhibitor00low000000
6-methyl-2-(methylthio)-N-phenyl-5-prop-2-enyl-4-pyrimidinamine
0
aryl sulfide00low000000
4-(2-pyridinylthio)benzofuro[3,2-d]pyrimidine
0
aryl sulfide00low000000
2-[[3-cyano-6-(2-furanyl)-4-(trifluoromethyl)-2-pyridinyl]thio]propanoic acid ethyl ester
0
aryl sulfide00low000000
N,N-di(propan-2-yl)-2-[(1-propyl-5-tetrazolyl)thio]acetamide
0
aryl sulfide00low000000
3-[(4,6-dimethyl-2-pyrimidinyl)thio]-N,N-dimethylpropanamide
0
aryl sulfide00low000000
2-[(2,5-dimethylphenyl)methylthio]-5-(3-pyridinyl)-1,3,4-oxadiazole
0
aryl sulfide00low000000
2-[[5-(2-furanyl)-4-(2-furanylmethyl)-1,2,4-triazol-3-yl]thio]-1-(4-morpholinyl)ethanone
0
aryl sulfide00low000000
N,N-diethyl-2-[(3-thiophen-2-yl-7-isothiazolo[4,5-d]pyrimidinyl)thio]acetamide
0
aryl sulfide00low000000
2-[[3-cyano-6-cyclopropyl-4-(trifluoromethyl)-2-pyridinyl]thio]acetic acid methyl ester
0
aryl sulfide00low000000
4-[(3-cyano-4,6-dimethyl-2-pyridinyl)thio]-3-oxobutanoic acid propan-2-yl ester
0
aryl sulfide;
isopropyl ester		00low000000
2-[[5-[[2-(3-chloroanilino)-4-thiazolyl]methyl]-4-(3-methoxypropyl)-1,2,4-triazol-3-yl]thio]acetic acid methyl ester
0
aryl sulfide00low000000
2-[(6-amino-3,5-dicyano-4-thiophen-2-yl-2-pyridinyl)thio]-N-(2-phenylethyl)acetamide
0
aryl sulfide00low000000
6-tert-butyl-3-cyclohexyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
0
aryl sulfide00low000000
2-[(3-cyano-6-cyclopropyl-4-thiophen-2-yl-2-pyridinyl)thio]acetamide
0
aryl sulfide00low000000
5-[2-[(4-chlorophenyl)thio]-1-oxoethyl]-2,4-dimethyl-1H-pyrrole-3-carboxylic acid methyl ester
0
aryl sulfide00low000000
4-(benzylsulfanyl)thieno[2,3-d]pyrimidine
0
aryl sulfide;
benzenes;
thienopyrimidine		00low000000
2-(Phenylthio)nicotinic acid
0
aryl sulfide00low000000
5-[(2-Chloro-6-fluorobenzyl)thio]-1,3,4-thiadiazol-2-amine
0
aryl sulfide00low000000
2-[(2-fluorophenyl)methylthio]-5-(4-methylphenyl)-1,3,4-oxadiazole
0
aryl sulfide00low000000
2-[(4-fluorophenyl)methylthio]-5-(2-methylphenyl)-1,3,4-oxadiazole
0
aryl sulfide00low000000
2-[(6-amino-3,5-dicyano-2-pyridinyl)thio]acetic acid ethyl ester
0
aryl sulfide00low000000
2-methyl-5-[(2-methyl-4-quinolinyl)thio]-1,3,4-thiadiazole
0
aryl sulfide00low000000
2-[(4-bromophenyl)methylthio]-5-(3-pyridinyl)-1,3,4-oxadiazole
0
aryl sulfide00low000000
GS4012 free base
0
aryl sulfide;
monomethoxybenzene;
pyridines		VEGF activator00low000000
2-(phenylmethylthio)-6,7-dihydro-5H-pyrrolo[1,2-a]imidazole
0
aryl sulfide00low000000
3-(2-methylpropylthio)-1H-1,2,4-triazol-5-amine
0
aryl sulfide00low000000
8-[(2-methyl-5-nitro-1,2,4-triazol-3-yl)thio]quinoline
0
aryl sulfide00low000000
2-[(3-fluorophenyl)methylthio]pyrimidine-4,6-diamine
0
aryl sulfide00low000000
2-(4-chlorophenyl)-4-(ethylthio)-6-(1-pyrrolidinyl)pyrimidine
0
aryl sulfide00low000000
2-[(2-chlorophenyl)methylthio]-6,7-dihydro-5H-pyrrolo[1,2-a]imidazole
0
aryl sulfide00low000000
N-[(2-methylphenyl)methyl]-2-[(4-methylphenyl)thio]acetamide
0
aryl sulfide00low000000
N,N-dimethyl-3-[(4-methylphenyl)thio]propanamide
0
aryl sulfide00low000000
3-[(2-chloro-6-fluorophenyl)methylthio]-4-ethyl-5-(2-furanyl)-1,2,4-triazole
0
aryl sulfide00low000000
3-cyclohexyl-5-(phenylmethylthio)-1,2,4-triazol-4-amine
0
aryl sulfide00low000000
N,N-dimethyl-2-[(2-phenyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)thio]ethanamine
0
aryl sulfide00low000000
3-chloro-4-[(1-ethyl-2-benzimidazolyl)thio]aniline
0
aryl sulfide00low000000
2-[[3-cyano-6-(2-furanyl)-4-(trifluoromethyl)-2-pyridinyl]thio]-N,N-diethylacetamide
0
aryl sulfide00low000000
5-[2-[(4-chlorophenyl)thio]-1-oxoethyl]-2,4-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester
0
aryl sulfide00low000000
2-[(4-chlorophenyl)thio]-N-(5-oxo-1-phenyl-4H-pyrazol-3-yl)acetamide
0
aryl sulfide00low000000
N-[3-(1,3-benzothiazol-2-ylthio)-4-hydroxyphenyl]-4-chlorobenzenesulfonamide
0
aryl sulfide00low000000
3-[5-[(4-chlorophenyl)methylthio]-1,3,4-oxadiazol-2-yl]-1-(phenylmethyl)-2-pyridinone
0
aryl sulfide00low000000
4-[(3-methylphenyl)thio]-2-phenyl-5-pyrimidinecarboxylic acid
0
aryl sulfide00low000000
3-phenyl-5-[(phenylthio)methyl]isoxazole
0
aryl sulfide00low000000
3-(4-chlorophenyl)-5-[(phenylthio)methyl]isoxazole
0
aryl sulfide00low000000
3-[4-ethyl-5-[(4-methylphenyl)methylthio]-1,2,4-triazol-3-yl]-1-phenyl-4-pyridazinone
0
aryl sulfide00low000000
5-[3-[(4-methylphenyl)methoxy]-2-thiophenyl]-3-(methylthio)-1H-1,2,4-triazole
0
aryl sulfide00low000000
5-methoxy-4-[(2-methoxyphenyl)thio]-2-phenylpyrimidine
0
aryl sulfide00low000000
3-[(4-ethylsulfonyl-2-nitrophenyl)thio]-4-methyl-1,2,4-triazole
0
aryl sulfide00low000000
1-[[1-oxo-2-[[5-(phenylmethylthio)-1,3,4-thiadiazol-2-yl]thio]ethyl]amino]-3-phenylthiourea
0
aryl sulfide00low000000
8-(dimethylamino)-3,4-dihydro-2H-pyrimido[2,1-b][1,3]thiazin-6-one
0
aryl sulfide00low000000
1-[[4-[(3,4-dichlorophenyl)thio]-3-pyridinyl]sulfonyl]-3-propylurea
0
aryl sulfide00low000000
N,N-dimethyl-3-[(2-phenyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)thio]-1-propanamine
0
aryl sulfide00low000000
2-tert-butyl-4-[(4-chlorophenyl)thio]-5-methyl-1H-pyrazol-3-one
0
aryl sulfide00low000000
benzoic acid [2-oxo-2-[2-(phenylthio)anilino]ethyl] ester
0
aryl sulfide00low000000
7-[[[5-(2,4-dimethylanilino)-1,3,4-thiadiazol-2-yl]thio]methyl]-5-thiazolo[3,2-a]pyrimidinone
0
aryl sulfide00low000000
N-phenyl-5-(propan-2-ylthio)-1,3,4-thiadiazol-2-amine
0
aryl sulfide00low000000
2-[(6-amino-3,5-dicyano-4-thiophen-2-yl-2-pyridinyl)thio]acetic acid ethyl ester
0
aryl sulfide00low000000
5-methyl-3-[3-[(5-methyl-1H-1,2,4-triazol-3-yl)thio]propylthio]-1H-1,2,4-triazole
0
aryl sulfide00low000000
N-[2-[(2-methylphenyl)methylthio]ethyl]-3-[(4-methylphenyl)thio]propanamide
0
aryl sulfide00low000000
1,3-dimethyl-5-[[5-(phenylthio)-2-furanyl]methylidene]-1,3-diazinane-2,4,6-trione
0
aryl sulfide00low000000
2-(1,3-benzothiazol-2-yl)-4-[(4-fluorophenyl)thio]-5-methyl-3-pyrazolamine
0
aryl sulfide00low000000
2-(4,6-dimethyl-2-pyrimidinyl)-4-[(4-fluorophenyl)thio]-5-methyl-3-pyrazolamine
0
aryl sulfide00low000000
2-[[5-(2-fluoroanilino)-1,3,4-thiadiazol-2-yl]thio]-N-(2-furanylmethyl)acetamide
0
aryl sulfide00low000000
1-(2-furanyl)-2-(1H-1,2,4-triazol-5-ylthio)ethanone
0
aryl sulfide00low000000
4-[(1-methyl-5-tetrazolyl)thio]-5-phenylthieno[2,3-d]pyrimidine
0
aryl sulfide;
thienopyrimidine		00low000000
2-chloro-N-[4-[(3,4-dimethylphenyl)thio]phenyl]acetamide
0
aryl sulfide00low000000
2-[(3,4-dimethylphenyl)thio]-3-pyridinecarboxylic acid
0
aryl sulfide00low000000
N-[6-amino-2,4-dioxo-1-(phenylmethyl)-5-pyrimidinyl]-2-[(5-amino-1,3,4-thiadiazol-2-yl)thio]-N-methylacetamide
0
aryl sulfide00low000000
2-[[5-(2-furanyl)-1,3,4-oxadiazol-2-yl]thio]-1-(1H-pyrrol-2-yl)ethanone
0
aryl sulfide00low000000
N-tert-butyl-2-[[4-(4-fluorophenyl)-2-thiazolyl]thio]acetamide
0
aryl sulfide00low000000
2-(4-chlorophenyl)-5-[[(4-methyl-2-thiazolyl)thio]methyl]-1,3,4-oxadiazole
0
aryl sulfide00low000000
s-phenyl-n-acetylcysteine
0
aryl sulfide;
S-substituted N-acetyl-L-cysteine		biomarker;
human urinary metabolite		00low000000
4-amino-2-(4-chlorophenyl)-6-(methylthio)pyrimidine-5-carbonitrile
0
aryl sulfide00low000000
[3,5-Bis(methylsulfanyl)-4-isothiazolyl]methanol
0
aryl sulfide00low000000
bi-78d3
0
aryl sulfide00low000000
2-[(4-chlorophenyl)thio]-1-methyl-3-indolecarboxaldehyde
0
aryl sulfide00low000000
1-[(3-chlorophenyl)methyl]-3-[5-(methylthio)-1,3,4-oxadiazol-2-yl]-2-pyridinone
0
aryl sulfide00low000000
2-[(2-methylphenyl)methylthio]-5-pyridin-4-yl-1,3,4-oxadiazole
0
aryl sulfide00low000000
3-[(2-sulfanylidene-3H-1,3,4-thiadiazol-5-yl)thio]propanoic acid ethyl ester
0
aryl sulfide00low000000
2-[(2-sulfanylidene-3H-1,3,4-thiadiazol-5-yl)thio]butanedioic acid
0
aryl sulfide00low000000
N-{2-[(4-amino-5-cyano-2-pyrimidinyl)sulfanyl]acetyl}-N'-phenylurea
0
aryl sulfide00low000000
2-[5-[(3-chlorophenyl)thio]-2-thiophenyl]pyridine
0
aryl sulfide00low000000
2-{5-[2-(Phenylthio)acetyl]-2-thienyl}acetic acid
0
aryl sulfide00low000000
2-[5-[2-[(4-methylphenyl)thio]-1-oxoethyl]-2-thiophenyl]acetic acid
0
aryl sulfide00low000000
2-[[2-methyl-5-nitro-3-(phenylmethyl)-4-imidazolyl]thio]-6-nitro-1H-benzimidazole
0
aryl sulfide00low000000
1-(2-furanyl)-3-(phenylthio)-3-thiophen-2-yl-1-propanone
0
aryl sulfide00low000000
1-(2-furanyl)-2-[(1-methyl-5-tetrazolyl)thio]ethanone
0
aryl sulfide00low000000
N-(1-adamantyl)-2-[(1-methyl-2-imidazolyl)thio]acetamide
0
aryl sulfide00low000000
u 0126
0
aryl sulfide;
dinitrile;
enamine;
substituted aniline		antineoplastic agent;
antioxidant;
apoptosis inducer;
EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor;
osteogenesis regulator;
vasoconstrictor agent		00low000000
zofenoprilate
0
aryl sulfide;
L-proline derivative;
N-acyl-L-amino acid;
thiol		anticonvulsant;
apoptosis inhibitor;
cardioprotective agent;
drug metabolite;
EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor;
vasodilator agent		00low000000
vx-745
0
aryl sulfide;
dichlorobenzene;
difluorobenzene;
pyrimidopyridazine		anti-inflammatory drug;
apoptosis inducer;
EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor		00low000000
N-methyl-2-[[3-[2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]thio]benzamide
0
aryl sulfide00low000000
2,2-dimethyl-N-[2,2,2-trichloro-1-(2-pyrimidinylthio)ethyl]propanamide
0
aryl sulfide00low000000
5-methyl-4-[(3-methyl-5-oxo-1,2-dihydropyrazol-4-yl)-[4-(methylthio)phenyl]methyl]-1,2-dihydropyrazol-3-one
0
aryl sulfide00low000000
1-(4-amino-1,2,5-oxadiazol-3-yl)-5-[(2-pyridinylthio)methyl]-4-triazolecarboxylic acid propan-2-yl ester
0
aryl sulfide;
azole;
isopropyl ester;
oxadiazole;
pyridines		00low000000
2-[[4-cyano-3-[(2-methoxy-2-oxoethyl)thio]-5-isothiazolyl]thio]acetic acid ethenyl ester
0
aryl sulfide00low000000
2-[(5-anilino-1,3,4-thiadiazol-2-yl)thio]ethanol
0
aryl sulfide00low000000
2-amino-4-[5-methyl-2-(methylthio)-3-thiophenyl]-5-oxo-1-(3-pyridinyl)-4,6,7,8-tetrahydroquinoline-3-carbonitrile
0
aryl sulfide00low000000
3-nitro-4-[[4-(2-oxolanylmethyl)-5-thiophen-2-yl-1,2,4-triazol-3-yl]thio]benzamide
0
aryl sulfide00low000000
1-(4-methoxyphenyl)-4-[(4-methylphenyl)thio]-6-oxo-3-pyridazinecarboxylic acid methyl ester
0
aryl sulfide00low000000
3-(phenylthio)-1-(1-pyrrolidinyl)-1-propanone
0
aryl sulfide00low000000
gw 7647
0
aryl sulfide;
monocarboxylic acid;
ureas		PPARalpha agonist00low000000
2-[(4-methyl-5-sulfanylidene-1,3,4-thiadiazol-2-yl)thio]acetic acid ethyl ester
0
aryl sulfide00low000000
4-[[7-methyl-4-(phenylthio)-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-2-yl]methyl]morpholine
0
aryl sulfide00low000000
2-[[4-(4-chlorophenyl)-5-sulfanylidene-1,3,4-thiadiazol-2-yl]thio]-N-(1,1-dioxo-3-thiolanyl)-N-(2-methylpropyl)acetamide
0
aryl sulfide00low000000
l 663536
0
aryl sulfide;
indoles;
monocarboxylic acid;
monochlorobenzenes		antineoplastic agent;
EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor;
leukotriene antagonist		00low000000
2-[(2-sulfanylidene-3H-1,3,4-thiadiazol-5-yl)thio]propanoic acid methyl ester
0
aryl sulfide00low000000
4-[(3-cyano-6,7-dihydro-5H-cyclopenta[b]pyridin-2-yl)thio]-3-oxobutanoic acid ethyl ester
0
aryl sulfide00low000000
5-[[(4-chlorophenyl)thio]methyl]-2-methyl-1H-pyrazol-3-one
0
aryl sulfide00low000000
1-(1-azepanyl)-2-[(5-methyl-4-nitro-1H-pyrazol-3-yl)thio]ethanone
0
aryl sulfide00low000000
1-(1-adamantyl)-2-[(1-oxido-2-pyridin-1-iumyl)thio]ethanone
0
aryl sulfide00low000000
2-[(2-nitro-3-pyridinyl)oxy]-N-[2-(phenylthio)phenyl]acetamide
0
aryl sulfide00low000000
3-amino-4-[(4-chlorophenyl)thio]benzoic acid methyl ester
0
aryl sulfide00low000000
5-[(3-nitro-2-pyridinyl)thio]-N-prop-2-enyl-1,3,4-thiadiazol-2-amine
0
aryl sulfide00low000000
3-(prop-2-enylthio)-[1,2,4]triazino[5,6-d][3,1]benzoxazepine
0
aryl sulfide00low000000
sulindac sulfide
0
aryl sulfide;
monocarboxylic acid;
organofluorine compound		antineoplastic agent;
apoptosis inducer;
non-steroidal anti-inflammatory drug		00low000000
cinanserin
0
aryl sulfide;
cinnamamides;
secondary carboxamide;
tertiary amino compound		anticoronaviral agent;
antiviral agent;
EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor		00low000000
5-[(2-chlorophenyl)thio]-3-(4-methylphenyl)-1,2,4-triazine-6-carboxylic acid ethyl ester
0
aryl sulfide00low000000
3-(2-oxolanylmethylthio)-5,6-diphenyl-1,2,4-triazine
0
aryl sulfide00low000000
axitinib
0
aryl sulfide;
benzamides;
indazoles;
pyridines		antineoplastic agent;
tyrosine kinase inhibitor;
vascular endothelial growth factor receptor antagonist		00low000000
2-[[4-methyl-5-(2-phenylethyl)-1,2,4-triazol-3-yl]thio]acetic acid methyl ester
0
aryl sulfide00low000000
2-[(3-iodophenyl)methylthio]-5-pyridin-4-yl-1,3,4-oxadiazole
0
aryl sulfide00low000000
n,n'-dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine
0
aryl sulfide00low000000
7-[(4-chlorophenyl)methylthio]-3-methyl-[1,3,4]thiadiazolo[2,3-c][1,2,4]triazin-4-one
0
aryl sulfide00low000000
7-[(3-chlorophenyl)methylthio]-3-methyl-[1,3,4]thiadiazolo[2,3-c][1,2,4]triazin-4-one
0
aryl sulfide00low000000
3-methyl-7-[(3-methylphenyl)methylthio]-[1,3,4]thiadiazolo[2,3-c][1,2,4]triazin-4-one
0
aryl sulfide00low000000
3-(ethylthio)-6-(2-furanyl)pyridazine
0
aryl sulfide00low000000
3-[(3-fluorophenyl)methylthio]-6-(2-furanyl)pyridazine
0
aryl sulfide00low000000
3-[(4-bromophenyl)methylthio]-6-(2-furanyl)pyridazine
0
aryl sulfide00low000000
3-[(4-chlorophenyl)methylthio]-6-(2-furanyl)pyridazine
0
aryl sulfide00low000000
5-(4-chlorophenyl)-4-[(1-methyl-5-tetrazolyl)thio]thieno[2,3-d]pyrimidine
0
aryl sulfide;
thienopyrimidine		00low000000
gw 501516
0
1,3-thiazoles;
aromatic ether;
aryl sulfide;
monocarboxylic acid;
organofluorine compound		carcinogenic agent;
PPARbeta/delta agonist		00low000000
4-[(4-methylphenyl)thio]-2-thieno[2,3-c]pyridinecarboxamide
0
aryl sulfide00low000000
cangrelor
0
adenosine 5'-phosphate;
aryl sulfide;
nucleoside triphosphate analogue;
organochlorine compound;
organofluorine compound;
secondary amino compound		P2Y12 receptor antagonist;
platelet aggregation inhibitor		00low000000
[2-[[2-[(dimethylamino)methyl]phenyl]thio]-5-iodophenyl]methanol
0
aryl sulfide00low000000
ticagrelor
0
aryl sulfide;
hydroxyether;
organofluorine compound;
secondary amino compound;
triazolopyrimidines		P2Y12 receptor antagonist;
platelet aggregation inhibitor		00low000000
vortioxetine
0
aryl sulfide;
N-arylpiperazine		antidepressant;
anxiolytic drug;
serotonergic agonist;
serotonergic antagonist		00low000000
n,n-dimethyl-2-(2-amino-4-fluorophenylthio)benzylamine
0
aryl sulfide00low000000
abt-737
0
aromatic amine;
aryl sulfide;
biphenyls;
C-nitro compound;
monochlorobenzenes;
N-arylpiperazine;
N-sulfonylcarboxamide;
secondary amino compound;
tertiary amino compound		anti-allergic agent;
anti-inflammatory agent;
antineoplastic agent;
apoptosis inducer;
B-cell lymphoma 2 inhibitor		00low000000
bay 60-6583
0
aminopyridine;
aromatic ether;
aryl sulfide;
cyanopyridine;
cyclopropanes;
monocarboxylic acid amide		adenosine A2B receptor agonist;
anti-inflammatory agent;
cardioprotective agent		00low000000
3-[(3-methylphenyl)methylthio]-6-thiophen-2-ylpyridazine
0
aryl sulfide00low000000
3-[[5-(4-ethylanilino)-1,3,4-thiadiazol-2-yl]thio]-2-oxolanone
0
aryl sulfide00low000000
3-(3-pyridinylmethylthio)-6-thiophen-2-ylpyridazine
0
aryl sulfide00low000000
sgx 523
0
aryl sulfide;
biaryl;
pyrazoles;
quinolines;
triazolopyridazine		c-Met tyrosine kinase inhibitor;
nephrotoxic agent		00low000000
navitoclax
0
aryl sulfide;
monochlorobenzenes;
morpholines;
N-sulfonylcarboxamide;
organofluorine compound;
piperazines;
secondary amino compound;
sulfone;
tertiary amino compound		antineoplastic agent;
apoptosis inducer;
B-cell lymphoma 2 inhibitor		00low000000
5-(4-methoxyphenyl)-4-[(1-methyl-5-tetrazolyl)thio]thieno[2,3-d]pyrimidine
0
aryl sulfide;
thienopyrimidine		00low000000
5-(4-bromophenyl)-4-[(1-methyl-5-tetrazolyl)thio]thieno[2,3-d]pyrimidine
0
aryl sulfide;
thienopyrimidine		00low000000
5-(2-methoxyphenyl)-4-[(1-methyl-5-tetrazolyl)thio]thieno[2,3-d]pyrimidine
0
aryl sulfide;
thienopyrimidine		00low000000
5-(3-methoxyphenyl)-4-[(1-methyl-5-tetrazolyl)thio]thieno[2,3-d]pyrimidine
0
aryl sulfide;
thienopyrimidine		00low000000
5-(3-fluorophenyl)-4-[(1-methyl-5-tetrazolyl)thio]thieno[2,3-d]pyrimidine
0
aryl sulfide;
thienopyrimidine		00low000000
4-[(1-methyl-5-tetrazolyl)thio]-5-[2-(trifluoromethyl)phenyl]thieno[2,3-d]pyrimidine
0
aryl sulfide;
thienopyrimidine		00low000000
4-[(1-methyl-5-tetrazolyl)thio]-5-[4-(trifluoromethyl)phenyl]thieno[2,3-d]pyrimidine
0
aryl sulfide;
thienopyrimidine		00low000000
5-(2-bromophenyl)-4-[(1-methyl-5-tetrazolyl)thio]thieno[2,3-d]pyrimidine
0
aryl sulfide;
thienopyrimidine		00low000000
5-(3-bromophenyl)-4-[(1-methyl-5-tetrazolyl)thio]thieno[2,3-d]pyrimidine
0
aryl sulfide;
thienopyrimidine		00low000000
5-(2-chlorophenyl)-4-[(1-methyl-5-tetrazolyl)thio]thieno[2,3-d]pyrimidine
0
aryl sulfide;
thienopyrimidine		00low000000
4-[4-[(1-methyl-5-tetrazolyl)thio]-5-thieno[2,3-d]pyrimidinyl]benzonitrile
0
aryl sulfide;
thienopyrimidine		00low000000
4-[(1-methyl-5-tetrazolyl)thio]-5-(4-nitrophenyl)thieno[2,3-d]pyrimidine
0
aryl sulfide;
thienopyrimidine		00low000000
5-(1,3-benzodioxol-5-yl)-4-(1-methyltetrazol-5-yl)sulfanylthieno[2,3-d]pyrimidine
0
aryl sulfide;
thienopyrimidine		00low000000
4-[(1-methyl-5-tetrazolyl)thio]-5-(3-thiophenyl)thieno[2,3-d]pyrimidine
0
aryl sulfide;
thienopyrimidine		00low000000
5-(2-benzofuranyl)-4-[(1-methyl-5-tetrazolyl)thio]thieno[2,3-d]pyrimidine
0
aryl sulfide;
thienopyrimidine		00low000000
4-[(1-methyl-5-tetrazolyl)thio]-5-(1H-pyrrol-2-yl)thieno[2,3-d]pyrimidine
0
aryl sulfide;
thienopyrimidine		00low000000
5-(3-methylsulfonylphenyl)-4-[(1-methyl-5-tetrazolyl)thio]thieno[2,3-d]pyrimidine
0
aryl sulfide;
thienopyrimidine		00low000000
4-[(1-methyl-5-tetrazolyl)thio]-5-(1-naphthalenyl)thieno[2,3-d]pyrimidine
0
aryl sulfide;
thienopyrimidine		00low000000
5-bromo-4-[(1-methyl-5-tetrazolyl)thio]thieno[2,3-d]pyrimidine
0
aryl sulfide;
thienopyrimidine		00low000000
monepantel
0
(trifluoromethyl)benzenes;
aromatic ether;
aryl sulfide;
nitrile;
secondary carboxamide		anthelminthic drug;
nematicide		00low000000
lesinurad
0
aryl sulfide;
cyclopropanes;
monocarboxylic acid;
naphthalenes;
organobromine compound;
triazoles		uricosuric drug00low000000
2-(methylthio)-6-(phenylmethyl)-1H-pyrimidin-4-one
0
aryl sulfide00low000000
2-[(4-chlorophenyl)methylthio]-1,5,6,7-tetrahydrocyclopenta[d]pyrimidin-4-one
0
aryl sulfide00low000000
2-[[2-[1-(2-methoxyethyl)-2,5-dimethyl-3-pyrrolyl]-2-oxoethyl]thio]-6-propyl-1H-pyrimidin-4-one
0
aryl sulfide00low000000
5-methyl-2-methylsulfanyl-6-propyl-1H-pyrimidin-4-one
0
aryl sulfide00low000000
8-((4-chlorophenyl)thio)cyclic-3',5'-gmp
0
3',5'-cyclic purine nucleotide;
aryl sulfide;
organochlorine compound;
ribonucleotide		protein kinase agonist00low000000
febantel
0
aryl sulfide00low000000
2-(butylthio)-1,5,6,7-tetrahydrocyclopenta[d]pyrimidin-4-one
0
aryl sulfide00low000000
2-(2-phenylethylthio)-1,5,6,7-tetrahydrocyclopenta[d]pyrimidin-4-one
0
aryl sulfide00low000000
5,6-dimethyl-N-(3-pyridinylmethyl)-4-thieno[2,3-d]pyrimidinamine
0
organic heterobicyclic compound;
organonitrogen heterocyclic compound;
organosulfur heterocyclic compound;
thienopyrimidine		00low000000
4-(5,6-dimethyl-1-benzimidazolyl)-5-phenylthieno[2,3-d]pyrimidine
0
organic heterobicyclic compound;
organonitrogen heterocyclic compound;
organosulfur heterocyclic compound;
thienopyrimidine		00low000000
4-(1-benzimidazolyl)-5-(4-methylphenyl)thieno[2,3-d]pyrimidine
0
organic heterobicyclic compound;
organonitrogen heterocyclic compound;
organosulfur heterocyclic compound;
thienopyrimidine		00low000000
5,6-dimethyl-2-(prop-2-enylthio)-4-thieno[2,3-d]pyrimidinamine
0
organic heterobicyclic compound;
organonitrogen heterocyclic compound;
organosulfur heterocyclic compound;
thienopyrimidine		00low000000
5,6-dimethyl-N-(thiophen-2-ylmethyl)-4-thieno[2,3-d]pyrimidinamine
0
organic heterobicyclic compound;
organonitrogen heterocyclic compound;
organosulfur heterocyclic compound;
thienopyrimidine		00low000000
4-[4-(phenylmethyl)-1-piperidinyl]thieno[2,3-d]pyrimidine
0
piperidines;
thienopyrimidine		00low000000
2-(1,3-dimethyl-2-benzimidazolylidene)-4-[(6-ethyl-4-thieno[2,3-d]pyrimidinyl)thio]-3-oxobutanenitrile
0
organic heterobicyclic compound;
organonitrogen heterocyclic compound;
organosulfur heterocyclic compound;
thienopyrimidine		00low000000
4-(4-methoxyanilino)-2,5-dimethyl-6-thieno[2,3-d]pyrimidinecarboxylic acid ethyl ester
0
organic heterobicyclic compound;
organonitrogen heterocyclic compound;
organosulfur heterocyclic compound;
thienopyrimidine		00low000000
5-(3,4-dimethoxyphenyl)-2-methyl-4-(4-methyl-1-piperidinyl)thieno[2,3-d]pyrimidine
0
dimethoxybenzene;
thienopyrimidine		00low000000
N-(3,4-dimethoxyphenyl)-6-phenyl-4-thieno[2,3-d]pyrimidinamine
0
dimethoxybenzene;
thienopyrimidine		00low000000
5,6-dimethyl-N-[2-methyl-2-(4-morpholinyl)propyl]-4-thieno[2,3-d]pyrimidinamine
0
organic heterobicyclic compound;
organonitrogen heterocyclic compound;
organosulfur heterocyclic compound;
thienopyrimidine		00low000000
4-(4-methyl-1-piperidinyl)-5-phenyl-2-(3-pyridinyl)thieno[2,3-d]pyrimidine
0
organonitrogen heterocyclic compound;
thienopyrimidine		00low000000
5-[[(5,6-dimethyl-4-thieno[2,3-d]pyrimidinyl)thio]methyl]-2-furancarboxylic acid methyl ester
0
organic heterobicyclic compound;
organonitrogen heterocyclic compound;
organosulfur heterocyclic compound;
thienopyrimidine		00low000000
5-methyl-N-[1-(phenylmethyl)-4-piperidinyl]-4-thieno[2,3-d]pyrimidinamine
0
piperidines;
thienopyrimidine		00low000000
4-[[2-(dimethylamino)-2-thiophen-2-ylethyl]amino]-5-methyl-6-thieno[2,3-d]pyrimidinecarboxylic acid ethyl ester
0
organic heterobicyclic compound;
organonitrogen heterocyclic compound;
organosulfur heterocyclic compound;
thienopyrimidine		00low000000
2-[(5,6-dimethyl-2-propyl-4-thieno[2,3-d]pyrimidinyl)thio]-1-(2-methyl-2,3-dihydroindol-1-yl)ethanone
0
organic heterobicyclic compound;
organonitrogen heterocyclic compound;
organosulfur heterocyclic compound;
thienopyrimidine		00low000000
2,5-dimethyl-4-(4-methyl-1-piperidinyl)-6-thieno[2,3-d]pyrimidinecarboxylic acid
0
organic heterobicyclic compound;
organonitrogen heterocyclic compound;
organosulfur heterocyclic compound;
thienopyrimidine		00low000000
N-(4-bromophenyl)-2-[(5,6-dimethyl-4-thieno[2,3-d]pyrimidinyl)thio]benzamide
0
benzamides;
thienopyrimidine		00low000000
7-[[5-(4-methoxyphenyl)-4-thieno[2,3-d]pyrimidinyl]oxy]-4-methyl-1-benzopyran-2-one
0
coumarins;
thienopyrimidine		00low000000
4-chloro-5-(2,3-dihydro-1,4-benzodioxin-3-yl)thieno[2,3-d]pyrimidine
0
benzodioxine;
thienopyrimidine		00low000000
4-[[2-[(1,1-dioxo-3-thiolanyl)amino]-2-oxoethyl]thio]-2,5-dimethyl-6-thieno[2,3-d]pyrimidinecarboxylic acid ethyl ester
0
organic heterobicyclic compound;
organonitrogen heterocyclic compound;
organosulfur heterocyclic compound;
thienopyrimidine		00low000000
3-[(2,5,6-trimethyl-4-thieno[2,3-d]pyrimidinyl)thio]-2-oxolanone
0
organic heterobicyclic compound;
organonitrogen heterocyclic compound;
organosulfur heterocyclic compound;
thienopyrimidine		00low000000
2,5-dimethyl-4-[[2-oxo-2-(4-phenylbutan-2-ylamino)ethyl]thio]-6-thieno[2,3-d]pyrimidinecarboxylic acid ethyl ester
0
organic heterobicyclic compound;
organonitrogen heterocyclic compound;
organosulfur heterocyclic compound;
thienopyrimidine		00low000000
N-(2,3-dihydro-1,4-benzodioxin-3-ylmethyl)-5,6-dimethyl-4-thieno[2,3-d]pyrimidinamine
0
benzodioxine;
thienopyrimidine		00low000000
org 41841
0
pyrimidines;
thienopyrimidine		00low000000
2-[(5,6-dimethyl-4-thieno[2,3-d]pyrimidinyl)amino]-1-(4-nitrophenyl)ethanol
0
organic heterobicyclic compound;
organonitrogen heterocyclic compound;
organosulfur heterocyclic compound;
thienopyrimidine		00low000000
gdc 0941
0
indazoles;
morpholines;
piperazines;
sulfonamide;
thienopyrimidine		EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor00low000000
4-[(1-methyl-5-tetrazolyl)thio]-5-(4-phenylphenyl)thieno[2,3-d]pyrimidine
0
biphenyls;
thienopyrimidine		00low000000
5-(4-dibenzothiophenyl)-4-[(1-methyl-5-tetrazolyl)thio]thieno[2,3-d]pyrimidine
0
dibenzothiophenes;
thienopyrimidine		00low000000
1-[2-[4-[(1-methyl-5-tetrazolyl)thio]-5-thieno[2,3-d]pyrimidinyl]phenyl]ethanone
0
aromatic ketone;
thienopyrimidine		00low000000
1-[3-[4-[(1-methyl-5-tetrazolyl)thio]-5-thieno[2,3-d]pyrimidinyl]phenyl]ethanone
0
aromatic ketone;
thienopyrimidine		00low000000
4-[4-(5,5-dimethyl-4H-thiazol-2-yl)-1-piperazinyl]-6-propylthieno[2,3-d]pyrimidine
0
N-arylpiperazine;
thienopyrimidine		00low000000
ConditionIndicatedStudiesFirst YearLast YearAverage AgeRelationship StrengthTrialspre-19901990's2000's2010'spost-2020
Inflammation0
1
2010201014.0high000100
Innate Inflammatory Response0
1
2010201014.0high000100